SV-ARB®
Brand Name:
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SV-ARB 50/100 Tablets
Composition: Sacubitril 24mg + Valsartan 26mg | Sacubitril 49mg + Valsartan 51mgPacking: 1x10
INDICATED IN:
Sacubitril-valsartan is prescribed to manage patients with heart failure with preserved ejection fraction (HFpEF). Sacubitril-valsartan is also FDA-approved for pediatric patients with heart failure.
Mode of Action
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SACUBITRIL
Sacubitril is a pro-drug that, upon activation, acts as a neprilysin inhibitor. The drug works by blocking the action of neprilysin, preventing the breakdown of natriuretic peptides, which leads to a prolonged duration of the favorable effects of these peptides. -
VALSARTAN
Valsartan is an angiotensin-receptor blocker used to manage hypertension alone or in combination with other antihypertensive agents and to manage heart failure in patients who are intolerant to ACE inhibitors.
Benefits & Usage
The benefits of sacubitril/valsartan in HF patients are felt to be due to the increased levels of peptides that are degraded by neprilysin and the simultaneous inhibition of the effects of AT1 receptor by valsartan.
Precautions
Alcohol
It is unsafe to consume alcohol with SV-ARB Tablets.
Pregnancy
Make sure your doctor knows if you are pregnant or planning to become pregnant.
Medicine
Do not take other medicines unless they have been discussed with your doctor.
Liver & Kidney
Should be used with caution in patients with liver & kidney disease.
